背景：Single Ig IL-1-related receptor （SIGIRR） or TIR8 is a member of Toll-like receptor-interleukin 1 receptor signaling （TLR-IL-1R） receptor superfamily.
Although SIGIRR/TIR8 shows the typical conserved motifs that characterize the IL-1R and Toll superfamily; it is structurally and functionally distinct from both.
SIGIRR/TIR8 has only one Ig domain in its extracellular portion whereas the IL-1R family contains three Ig folds.
An unusually long cytoplasmic domain is reminiscent of the structure of drosophila Toll; yet the SIGIRR peptide sequence is more closely related to IL-1RI.
SIGIRR/TIR8 was mainly expressed in mouse and human epithelial tissues such as kidney; lung and gut.
Resting and activated T and B lymphocytes and monocytes-macrophages expressed little or no SIGIRR/TIR8; with the exception of the mouse GG2EE macrophage line.
Inflammation is enhanced in SIGIRR-deficient mice.
SIGIRR negatively modulates immune responses.
Inflammation is enhanced in SIGIRR-deficient mice; as shown by their enhanced chemokine induction after IL-1 injection and reduced threshold for lethal endotoxin challenge.
仕様
サイズ：1mg
種由来：Human
発現宿主：HEK293 Cells
純度：＞95 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：Q6IA17-1
アミノ酸配列：Met 1-His 118
遺伝子構造：A DNA sequence encoding the human SIGIRR （Q6IA17-1） extracellular domain （Met 1-His 118） was expressed; fused with a polyhistidine tag at the C-terminus and a signal peptide at the N-terminus.
別名（遺伝子名）：TIR8
分子量：14 kDa
組成：Lyophilized from sterile PBS; pH 7.4
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
