背景：Myeloid cell surface antigen CD33 also known as Sialic acid binding Ig-like lectin 3, CD33 antigen or Siglec-3, is a member of the immunoglobulin superfamily and SIGLEC （sialic acid binding Ig-like lectin） family.
This Single-pass type I membrane protein contains 1 Ig-like C2-type （immunoglobulin-like） domain and 1 Ig-like V-type （immunoglobulin-like） domain.
CD33 /Siglec-3 is a putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells.
CD33 /Siglec-3 preferentially binds to alpha-2,6-linked sialic acid.
The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase（s） via their SH2 domain（s） that block signal transduction through dephosphorylation of signaling molecules.
CD33/Siglec-3 induces apoptosis in acute myeloid leukemia （in vitro）.
CD33/Siglec-3 can function as a sialic acid-dependent cell adhesion molecule and that binding can be modulated by endogenous sialoglycoconjugates when CD33 is expressed in a plasma membrane.
仕様
サイズ：1mg
種由来：Human
発現宿主：HEK293 Cells
純度：＞90 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：AAH28152.1
アミノ酸配列：Met 1-His259
遺伝子構造：A DNA sequence encoding the human CD33 （AAH28152.1） （Met1-His259） was expressed with a C-terminal polyhistidine tag.
組成：Lyophilized from sterile PBS, pH 7.4, 10％ glycerol
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
