背景：CD47 contains 1 Ig-like V-type （immunoglobulin-like） domain and is a receptor for the C-terminal cell binding domain of thrombospondin.
It may play a role in membrane transport and signal transduction.
CD47 is also a membrane protein; which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix.
It is very broadly distributed on normal adult tissues; as well as ovarian tumors; being especially abundant in some epithelia and the brain.
CD47 may play a role in membrane transport and/or integrin dependent signal transduction.
It may prevent premature elimination of red blood cells.
It also may be involved in membrane permeability changes induced following virus infection.
By acting as an adhesion receptor for THBS1 on platelets; CD47 plays a role in both cell adhesion and in the modulation of integrins.
It also plays an important role in memory formation and synaptic plasticity in the hippocampus.
仕様
サイズ：1mg
種由来：Human
発現宿主：HEK293 Cells
純度：＞95 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_942088.1
アミノ酸配列：Met 1-Pro139
遺伝子構造：A DNA sequence encoding the human CD47 （NP_942088.1） （Met1-Pro139） was expressed with the Fc region of human IgG1 at the C-terminus.
別名（遺伝子名）：IAP;MER6;OA3
分子量：40.7 kDa
組成：Lyophilized from sterile PBS; pH 7.4
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
