背景：Carbonic anhydrase 5B; also known as carbonate dehydratase VB; carbonic anhydrase VB; CA-VB and CA5B; is amember of the alpha-carbonic anhydrase family.
The strongest expression of CA5B / CA-VB is in heart; pancreas; kidney; placenta; lung; and skeletal muscle.
It is not expressed in liver.
Carbonic anhydrases （CAs） are a large family of zinc metalloenzymes first discovered in 1933 that catalyze the reversible hydration of carbon dioxide.
CAs participate in a variety of biological processes; including respiration; calcification; acid-base balance; bone resorption; and the formation of aqueous humor; cerebrospinal fluid; saliva; and gastric acid.
CAs show extensive diversity in tissue distribution and in their subcellular localization.
CA5B / CA-VB is localized in the mitochondria and shows the highest sequence similarity to the other mitochondrial CA5A / CA-VA.
CA5B / CA-VB has a wider tissue distribution than CA5A / CA-VA; which is restricted to the liver.
The differences in tissue distribution suggest that the two mitochondrial carbonic anhydrases evolved to assume different physiologic roles.
CA5A / CA-VA is activated by histamine; L-adrenaline; L- and D-histidine; and L- and D-phenylalanine.
It is inhibited by coumarins; sulfonamide derivatives such as acetazolamide and Foscarnet （phosphonoformate trisodium salt）.
CA5B / CA-VB is inhibited by coumarins; sulfonamide derivatives such as acetazolamide （AZA）; saccharin and Foscarnet （phosphonoformate trisodium salt）.
仕様
サイズ：50ug
種由来：Human
発現宿主：E.coli
純度：＞97 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：Please contact us for more information.
アクセッションNo.：Q9Y2D0
アミノ酸配列：Cys 34-Pro 317
遺伝子構造：A DNA sequence encoding the mature form of human CA5B （Q9Y2D0） （Cys 34-Pro 317） was fused with a polyhistidine tag at the C-terminus and an initial Met at the N-terminus.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
