背景：Myocilin, also known as Trabecular meshwork-induced glucocorticoid response protein, MYOC and GLC1A, is a protein which contains oneolfactomedin-like domain.
Myocilin / MYOC may participate in the obstruction of fluid outflow in the trabecular meshwork.
Myocilin / MYOC is expressed in large amounts in various types of muscle, ciliary body, papillary sphincter, skeletal muscle, heart and other tissues.
Myocilin / MYOC is expressed predominantly in the retina.
In normal eyes, it is found in the inner uveal meshwork region and the anterior portion of the meshwork.
In contrast, in many glaucomatous eyes, it is found in more regions of the meshwork and appeared more intensively than in normal eyes, regardless of the type or clinical severity of glaucoma.
Defects in Myocilin / MYOC may contribute to primary congenital glaucoma type 3A （GLC3A）.
Defects in MYOC may also contribute to this phenotype via digenic inheritance.
GLC3A is an autosomal recessive form of primary congenital glaucoma （PCG）.
PCG is characterized by marked increase of intraocular pressure at birth or early choldhood, large ocular globes （buphthalmos） and corneal edema.
仕様
サイズ：50ug
種由来：Human
発現宿主：HEK293 Cells
純度：＞95 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：Q99972
アミノ酸配列：Met 1-Met 504
遺伝子構造：A DNA sequence encoding the full length of human MYOC （Q99972） （Met 1-Met 504） was fused with a polyhistidine tag at the C-terminus.
別名（遺伝子名）：GLC1A;GPOA;JOAG;JOAG1;myocilin;TIGR
分子量：54.7 kDa
組成：Lyophilized from sterile PBS, pH 7.4
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
