背景：OX-40L, also known as TNFSF4 and CD252, is a cytokine that belongs to the tumor necrosis factor （TNF） ligand family.
OX-40L is an important costimulatory molecule that plays a crucial role in the regulation of T-cell-mediated immunity.
The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus （SLE）, carotid artery disease and cancer.
OX-40L is a ligand for receptor TNFRSF4/OX4.
It is found to play a role in T cell antigen-presenting cell （APC） interactions.
In surface Ig- and CD40-stimulated B cells, this cytokine along with CD70 has been shown to provide CD28-independent costimulatory signals to T cells.
This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells.
仕様
サイズ：1mg
種由来：Human
発現宿主：HEK293 Cells
純度：＞90 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_003317.1
アミノ酸配列：Gln51-Leu183
遺伝子構造：A DNA sequence encoding the human TNFSF4 （NP_003317.1） （Gln51-Leu183） was expressed with the Fc region of mouse IgG1 at the N-terminus.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
