背景：Tumor necrosis factor receptor superfamily; member 19 （TNFRSF19）; also known as TAJ-alpha or TROY; is a member of the TNF-receptor superfamily.
TNFRSF19/TROY expression is detected in the pulmonary epithelium and the ductal epithelium of the prostate and parotid glands.
TNFRSF19/TROY expression is detected in some adenocarcinoma cell lines that arise from this tissue.
It has been shown to interact with TRAF family members; and to activate JNK signaling pathway when overexpressed in cells.
TNFRSF19/TROY is capable of inducing apoptosis by a caspase-independent mechanism; and it is thought to play an essential role in embryonic development.
TNFRSF19/TROY was negatively regulated by adipogenic transcription factor CCAAT/enhancer-binding proteins （C/EBP）.
TNFRSF19 signals activation of the Jnk pathway and induces cell death.
Overexpression of TNFRSF19 also signals NFB activation; comparable and similar to that by p75NGFR.
TNFRSF19/TROY is capable of activating key signaling pathways of the TNF receptor family; and its predominant expression patterns suggest that it plays a role in the growth and regulation of epithelial tissues.
仕様
サイズ：1mg
種由来：Human
発現宿主：HEK293 Cells
純度：＞95 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：Q9NS68-2
アミノ酸配列：Met 1-Leu170
遺伝子構造：A DNA sequence encoding the human TNFRSF19 （Q9NS68-2） （Met1-Leu170） was expressed with a polyhistidine tag at the C-terminus.
別名（遺伝子名）：TAJ;TAJ-alpha;TNFRSF19;TRADE;TROY
分子量：16.9 kDa
組成：Lyophilized from sterile PBS; pH 7.4
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
