背景：SCN3B （sodium channel; voltage-gated; type III; beta ;human IgG1-Fc chimera） belongs to the sodium channel auxiliary subunit SCN3B family.
It contains 1 Ig-like C2-type （immunoglobulin-like） domain.
Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits.
They are responsible for the generation and propagation of action potentials in neurons and muscle.
SCN3B gene encodes one member of the sodium channel beta subunit gene family; and influences the inactivation kinetics of the sodium channel.
Two alternatively spliced variants; encoding the same protein; have been identified.
Defects in SCN3B are the cause of Brugada syndrome type 7.
A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram.
It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body.
When this situation occurs （called ventricular fibrillation）; the individual will faint and may die in a few minutes if the heart is not reset.
仕様
サイズ：1mg
種由来：Human
発現宿主：HEK293 Cells
純度：＞90 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：P01859
アミノ酸配列：Glu 99-Lys 327; 257Ser/Ala
遺伝子構造：A DNA sequence encoding the human IgG2 Fc region （P01859） （Glu 99-Lys 327; 257Ser/Ala） was expressed and purified.
別名（遺伝子名）：Ig gamma-2 chain C region,IgG2 Fc
分子量：25 kDa
組成：Lyophilized from sterile PBS; pH 7.4
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
