背景：Glutaminyl cyclase, also known as QPCT, can promote the N-terminal cyclization reaction of N-terminal pyroglutamate（pGlu）.
The pGlu formation from its glutaminyl precursor is required in the maturation of numerous bioactive peptides, while the aberrant formation of pGlu may be related to several pathological processes, such as osteoporosis and amyloidotic diseases.
Glutaminyl cyclase's structure reveals an alpha/beta scaffold akin to that of two-zinc exopeptidases but with several insertions and deletions, particularly in the active-site region.
Glutaminyl cyclase's amino acid sequence of this enzyme is 86％ identical to that of bovine glutaminyl cyclase.
It is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides.
仕様
サイズ：50ug
種由来：Human
発現宿主：Baculovirus-Insect Cells
純度：＞95 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：Q16769-1
アミノ酸配列：Ala33-Leu361
遺伝子構造：A DNA sequence encoding the human QPCT （Q16769-1） （Ala33-Leu361） was fused with a polyhistide tag at the N-terminus.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
