84-9361-79　Recombinant Human TSPAN8/Tetraspanin 8 Protein （His Tag） 50ug　PKSH030523

特徴

• 背景：Tetraspanin 8 （TSPAN8） as an important modulator of melanoma invasiveness; and several of its transcriptional regulators; which affect TSPAN8 expression during melanoma progression toward an invasive stage.
• p53 as a negative regulator of Tspan8 expression.
• p53 as a regulator of melanoma invasion and the concept that reactivating p53 could provide a strategy for modulating not only proliferative but also invasive capacity in melanoma treatment.
• Tetraspanin 8 （TSPAN8） is a tumor-associated antigen implicated in tumor progression and metastasis.
• TSPAN8 may play an important role in mCRC cell invasion.
• TSPAN8 was overexpressed in human gastric cancer tissues and gastric cancer cell lines compared with the normal.
• TSPAN8 overexpression promoted cell proliferation and invasion; while TSPAN8 suppression inhibited cell proliferation and invasion.
• TSPAN8 could activate the ERK MAPK pathway in gastric cancer cells; and MEK-ERK inhibition reversed the effects of TSPAN8 overexpression on cell proliferation and invasion.