背景：LAG3, also known as CD223 and Lymphocyte activation gene 3, belongs to immunoglobulin （Ig） superfamily.
LAG3 contains 4 extracellular Ig-like domains.
The LAG3 gene contains 8 exons.
It is selectively expressed in activated T and NK cells.
LAG3 has a negative regulatory function in T cells.
It also acts as as a new marker of T cell induced B cell activation.
As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signalling, leading to increased antigen-specific T-cell responses in vivo.
仕様
サイズ：500ug
種由来：Human
発現宿主：HEK293 Cells
純度：＞95 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_002277.4
アミノ酸配列：Met 1-Leu450
遺伝子構造：A DNA sequence encoding the human LAG3 （NP_002277.4） （Met1-Leu450） was expressed with the Fc region of human IgG1 at the C-terminus.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
