背景：Dipeptidyl peptidase-4 （DPP4） or adenosine deaminase complexing protein 2 （ADCP 2） or T-cell activation antigen CD26 is a serine exopeptidase belonging to the S9B protein family that cleaves X-proline dipeptides from the N-terminus of polypeptides, such as chemokines, neuropeptides, and peptide hormones.
The enzyme is a type II transmembrane glycoprotein, expressed on the surface of many cell types.
It is also present in serum and other body fluids in a truncated form （sCD26/DPPIV）.
The soluble CD26 （sCD26） as a tumour marker for the detection of colorectal cancer （CRC） and advanced adenomas.
As both a regulatory enzyme and a signalling factor, DPP4 has been evaluated and described in many studies.
DPP4 inhibition results in increased blood concentration of the incretin hormones glucagon-like peptide-1 （GLP-1） and gastric inhibitory polypeptide （GIP）.
This causes an increase in glucose-dependent stimulation, resulting in a lowering of blood glucose levels.
Recent studies have shown that DPP4 inhibitors can induce a significant reduction in glycosylated haemoglobin （HbA（1c）） levels, either as monotherapy or as a combination with other antidiabetic agents.
Research has also demonstrated that DPP4 inhibitors portray a very low risk of hypoglycaemia development, and are a new pharmacological class of drugs for treating Type 2 diabetes.
仕様
サイズ：50ug
種由来：Human
発現宿主：HEK293 Cells
純度：＞95 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_001926.2
アミノ酸配列：Asn 29-Pro 766
遺伝子構造：A DNA sequence encoding the extracellular domain （Asn 29-Pro 766） of the mature form of human DPPIV （NP_001926.2） was expressed with the fused Fc region of human IgG1 at the N-terminus.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
