背景：Epithelial Cell Adhesion Molecule （EpCAM）, also known as GA733-2 antigen, is a type ＆acirc;＆hellip;transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane domain and a cytoplasmic domain.
It modulates cell adhesion and proliferation.
Its overexpression has been detected in many epithelial tumours and has been associated with high stage, high grade and a worse survival in some tumour types.
EpCAM has been shown to function as a calcium-independent homophilic cell adhesion molecule that does not exhibit any obvious relationship to the four known cell adhesion molecule superfamilies.
However, recent insights have revealed that EpCAM participates in not only cell adhesion, but also in proliferation, migration and differentiation of cells.
In addition, recent study revealed that EpCAM is the Wnt-beta-catenin signaling target gene and may be used to facilitate prognosis.
It has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway.
仕様
サイズ：1mg
種由来：Human
発現宿主：HEK293 Cells
純度：＞96 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_002345.1
アミノ酸配列：Met 1-Lys265
遺伝子構造：A DNA sequence encoding the extracellular domain （Met 1-Lys265） of human EpCAM （NP_002345.1） was fused with a polyhistidine tag at the C-terminus.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
