背景：Receptor tyrosine kinase-like orphan receptor 1 （ROR1）, also known as neurotrophic tyrosine kinase, it is a member of the ROR family within receptor tyrosine kinases （RTK） superfamily.
Human ROR1 is a type I transmembrane protein with 937 amino acids （aa） in length.
It contains a 29 aa signal sequence, a 377 aa extracellular domain （ECD）, a 21 aa transmembrane segment, and a 510 aa cytoplasmic region.
ROR1 expressed strongly in human heart, lung and kidney, but weakly in the CNS.
At developmental stage, it expressed at high levels during early embryonic development.
ROR1 has been shown to have very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo.
It may act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling.
仕様
サイズ：1mg
種由来：Human
発現宿主：HEK293 Cells
純度：＞95 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_005003.2
アミノ酸配列：Met 1-Glu403
遺伝子構造：A DNA sequence encoding the human ROR1 （NP_005003.2） （Met1-Glu403） was expressed with a polyhistidine tag at the C-terminus.
別名（遺伝子名）：dJ537F10.1;NTRKR1
分子量：43.4 kDa
組成：Lyophilized from sterile PBS, pH 7.4
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
