背景：Receptors for the Fc region of IgG （FcγR） are members of the Ig superfamily that function in the activation or inhibition of immune responses.
Human FcγRs are divided into three classes designated FcγRI （CD64）, FcγRII （CD32）, and FcγRIII （CD16）, which generate multiple isoforms, are recognized.
The activating- type receptor either has or associates non-covalently with an accessory subunit that has an immunoreceptor tyrosine-based activation motif （ITAM） in its cytoplasmic domain.
FcγRI binds IgG with high affinity and functions during early immune responses, whereas FcγRII and RIII are low affinity receptors that recognize IgG as aggregates surrounding multivalent antigens during late immune responses.
Three genes for human FcγRII （A, B, and C） and one for mouse （FcγRIIB）, encoding type I transmembrane proteins with ITAM motifs （FcγRII A and C） or ITIM motifs （FcγRIIB） in their cytoplasmic domains, have been identified.
Human CD32, also known as Low affinity immunoglobulin γ Fc region receptor II-a （IgG Fc receptor II-a）, FcγRII A or FCGR2A Protein, is expressed on cells of both myeloid and lymphoid lineages as well as on cells of non-hematopoietic origin.
Associated with an ITAM-bearing adapter subunit, FcRγ, CD32a （FcγRII A） delivers an activating signal upon ligand binding, and results in the initiation of inflammatory responses including cytolysis, phagocytosis, degranulation, and cytokine production.
The responses can be modulated by signals from the co-expressed inhibitory receptors such as Fcγ RII B, and the strength of the signal is dependent on the ratio of expression of the activating and inhibitory receptors.
仕様
サイズ：1mg
種由来：Human
発現宿主：HEK293 Cells
純度：＞90 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：AAA35827.1
アミノ酸配列：Met 1-Ile 218
遺伝子構造：A DNA sequence encoding the extracellular domain （Met 1-Ile 218） of human CD32a （AAA35827.1） was fused with the Fc region of human IgG1 at the C-terminus. It is identical to FCGR2A131H/R in the reference.
別名（遺伝子名）：Low affinity immunoglobulin gamma Fc region receptor II-a; IgG Fc receptor II-a; CDw32; Fc-gamma RII-a; Fc-gamma-RIIa; FcRII-a; CD32; FCGR2A; FCG2; FCGR2A1;IGFR2;CD32A;CDw32;Fc gamma RIIA;FCG2;FcGR;FCGR5
分子量：47.3 kDa
組成：Lyophilized from sterile PBS, pH 7.5
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
