84-9361-45　Recombinant Human CD32a/FCGR2A Protein （167 His, His Tag）（Active） 1mg　PKSH030294

特徴

• 背景：Receptors for the Fc region of IgG （FcγR） are members of the Ig superfamily that function in the activation or inhibition of immune responses.
• Human FcγRs are divided into three classes designated FcγRI （CD64）; FcγRII （CD32）; and FcγRIII （CD16）; which generate multiple isoforms; are recognized.
• The activating- type receptor either has or associates non-covalently with an accessory subunit that has an immunoreceptor tyrosine-based activation motif （ITAM） in its cytoplasmic domain.
• FcγRI binds IgG with high affinity and functions during early immune responses; whereas FcγRII and RIII are low affinity receptors that recognize IgG as aggregates surrounding multivalent antigens during late immune responses.
• Three genes for human FcγRII （A; B; and C） and one for mouse （FcγRIIB）; encoding type I transmembrane proteins with ITAM motifs （FcγRII A and C） or ITIM motifs （FcγRIIB） in their cytoplasmic domains; have been identified.
• Human CD32; also known as Low affinity immunoglobulin γ Fc region receptor II-a （IgG Fc receptor II-a）; FcγRII A or FCGR2A Protein; is expressed on cells of both myeloid and lymphoid lineages as well as on cells of non-hematopoietic origin.
• Associated with an ITAM-bearing adapter subunit; FcRγ; CD32a （FcγRII A） delivers an activating signal upon ligand binding; and results in the initiation of inflammatory responses including cytolysis; phagocytosis; degranulation; and cytokine production.
• The responses can be modulated by signals from the co-expressed inhibitory receptors such as Fcγ RII B; and the strength of the signal is dependent on the ratio of expression of the activating and inhibitory receptors.