84-9359-82　［取扱停止］Recombinant Mouse ALPL protein（His tag） 100ug　PDMM100007

特徴

• 背景：Alkaline phosphatase （ALPL） is a hydrolase enzyme responsible for removing phosphate groups from many types of molecules, including nucleotides, proteins, and alkaloids.
• The process of removing the phosphate group is called dephosphorylation.
• As the name suggests, alkaline phosphatases are most effective in an alkaline environment.
• It is sometimes used synonymously as basic phosphatase.
• Alkaline phosphatases （APs） are ubiquitous in many species, from bacteria to human.
• Four genes encode AP isoenzymes in humans and rodents.
• Three AP genes are expressed in a tissue-specific manner （i.e., placental, embryonic, and intestinal AP isoenzymes）.
• Expression of the fourth AP gene is nonspecific to a single tissue and is especially abundant in bone, liver, and kidney.
• This isoenzyme is also called tissue-nonspecific alkaline phosphatase （TNAP）.
• The enzyme tissue non-specific alkaline phosphatase （TNAP） belongs to the ectophosphatase family.
• TNAP is present in large amounts in bone in which it plays a role in mineralization.