特徴

• 背景：CD16 antigen, also known as Natural killer cell receptor BY55 and CD16, is a cell membrane protein which contains one Ig-like V-type （immunoglobulin-like） domain.
• CD16 is a GPI-anchored lymphocyte surface receptor in which expression is mostly restricted to the highly cytotoxic CD56（dim）CD16（+） peripheral blood NK subset.
• CD16 is a receptor showing broad specificity for both classical and non-classical MHC class I molecules.
• CD16 is expressed in spleen, peripheral blood, and small intestine.
• Expression of CD16 is restricted to functional NK and T cytotoxic lymphocytes.
• CD16 acts as a co-activator receptor for CD3-induced proliferation of CD4+ CD16+ T cells isolated from inflammatory skin lesions.
• Unique CD4+ CD16+ lymphocyte subset may play a role in the pathogenesis of skin inflammation.
• Activated NK lymphocytes release a soluble form of CD16 that functionally impairs the MHC-I-specific cytotoxic CD8（+） T lymphocyte responsiveness.