特徴

• 背景：Leukocyte Immunoglobulin-like Receptor Subfamily A Member 5（LILRA5）is a member of the leukocyte immunoglobulin-like receptors （LILR）, comprise a family of activating and inhibitory type immunoreceptors.
• LILRA5 consists of a 227 amino acid （aa） extracellular domain （ECD）, a 21 aa transmembrane segment, and a 10 aa cytoplasmic tail.
• The ECD contains two Ig-like domains and the transmembrane segment contains a positively charged aspartic acid residue which may mediate its association with the signaling molecule, FcR common gamma chain.
• LILRA5 is expressed by monocytes, macrophages, and neutrophils.
• Cross-linking of LILRA5 on monocytes induces the expression of pro-inflammatory cytokines （IL-1beta, IL-6, TNF-alpha） as well as the anti-inflammatory IL-10.
• It can be detected in tissues of the hematopoietic system, including bone marrow, spleen, lymph node and peripheral leukocytes.
• Crosslink of ILT-11 on the surface of monocytes has been shown to induce calcium flux and secretion of several proinflammatory cytokines, which suggests the roles of this protein in triggering innate immune responses.