84-9356-85 ［取扱停止］Recombinant Human SerpinE1/PAI-1 Protein （His Tag） 100ug PDMH100015
[Elabscience]
特徴
- 背景：Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases.
- They are the largest and most diverse family of serine protease inhibitors which are involved in a number of fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation and tumor suppression and are expressed in a cell-specific manner.
- Serpin E1 is a secreted protein which belongs to the Serpin family.
- Serpin E1 acts as 'bait' for tissue plasminogen activator, urokinase, and protein C.
- Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis.
- Defects in SERPINE1 are characterized by abnormal bleeding due to Serpin E1 defect in the plasma.
- High concentrations of Serpin E1 have been associated with thrombophilia which is an autosomal dominant disorder in which affected individuals are prone to develop serious spontaneous thrombosis.
仕様
- サイズ：100ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：＞95 ％ as determined by reducing SDS-PAGE.
- エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
- アクセッションNo.：P05121
- アミノ酸配列：Val24-Pro402
- 遺伝子構造：Recombinant Human Serine Protease Inhibitor-clade E1 is produced by our Mammalian expression system and the target gene encoding Val24-Pro402 is expressed with a 6His tag at the C-terminus.
- 別名（遺伝子名）：Plasminogen Activator Inhibitor 1; PAI; PAI-1; Endothelial Plasminogen Activator Inhibitor; Serpin E1; SERPINE1; PAI1; PLANH1;SERPINE1
- 分子量：43.8 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
- 保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
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84-9356-85
Recombinant Human SerpinE1/PAI-1 Protein （His Tag） 100ug
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84-9356-84
Recombinant Human SerpinE1/PAI-1 Protein （His Tag） 20ug
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