84-9356-83　Recombinant Human Myeloperoxidase/MPO Protein （His Tag） 100ug　PDMH100014

特徴

• 背景：Myeloperoxidase （MPO） is a heme-containingenzyme belonging to the XPO subfamily of peroxidases.
• It is an abundant neutrophil and monocyte glycoprotein thatcatalyzes the hydrogen peroxide-dependentconversion of chloride, bromide, and iodide to multiple reactive species.
• Post-translationalprocessing of MPO involvesthe insertion of a heme moiety and the proteolytic removal of both a propeptide and a 6 aa internal peptide.
• This results in a disulfide-linkeddimer composed of a60 kDa heavy and 12 kDa light chain that associate into a 150 kDa enzymatically active tetramer.
• The tetramer contains two heme groups and one disulfide bondbetween the heavy chains.
• Alternate splicing generates two additional isoforms of MPO, one with a 32 aa insertion in the light chain, and another with a deletion ofthe signal sequence and part of the propeptide.
• Human and mouse MPO share 87％ aa sequence identity.
• MPO activity results in protein nitrosylation and theformation of 3-chlorotyrosineand dityrosine crosslinks.
• MPO is also associated with a variety of other diseases, and inhibits vasodilation in inflammation by depleting the levelsof NO.
• Serum albumin functions as a carrier protein during MPO movement to the basolateral side of epithelial cells.
• MPO is stored in neutrophil azurophilicgranules.
• Upon cellular activation, it is deposited into pathogen-containingphagosomes.