84-9356-67　［取扱停止］Recombinant Human TIM-3/HAVCR2 Protein （His Tag） 100ug　PDMH100006

特徴

• 背景：Hepatitis A virus cellular receptor 2 （HAVCR2）; formerly known as T cell immunoglobulin and mucin domain-3 （TIM-3）; is a transmembrane glycoprotein expressed on the surface of terminally differentiated Th1 cells but not on Th2 cells.
• It was the first surface molecule that specifically identifies Th1 cells in both mice and human.
• Recently; identification of Galectin-9 as a ligand for TIM-3 has established the TIM-3-Galectin-9 pathway as an important regulator of Th1 immunity and tolerance induction.
• Engagement of Tim-3 by its ligand galectin-9 negatively regulates IFN-gamma secretion and influences the ability to induce T cell tolerance in both mice and man.
• It suggests a novel paradigm in which dysregulation of the TIM-3-galectin-9 pathway could underlie chronic autoimmune disease states; such as multiple sclerosis.
• Recent work has explored the role of TIM-3 in systemic lupus erythematosus （SLE）; and their results indicate that TIM-3 may represent a novel target for the treatment of SLE.
• Numerous studies have demonstrated that Tim-3 influences autoimmune diseases; including diabetes and multiple sclerosis; and its role in other inflammatory diseases including allergies and cancer is beginning to become clear.
• In tumor rejection model; soluble form of Tim-3 （sTim-3） significantly impaired T cell antitumor immunity; evidenced by decreased antitumor CTL activity and reduced amount of tumor-infiltrating lymphocytes in tumor.
• sTim-3 as an immunoregulatory molecule that may be involved in the negative regulation of T cell-mediated immune response.