84-9356-64 ［取扱停止］Recombinant Human B7-H4/VTCN1 Protein （aa 29-258, His Tag） 20ug PDMH100005
[Elabscience]
特徴
- 背景：V-set domain-containing T-cell activation inhibitor 1; also known as B7X; B7H4; B7S1; and VTCN1; is a single-pass type? membrane protein belonging to the B7 family of costimulatory proteins.
- These proteins are expressed on the surface of antigen-presenting cells and interact with ligands on T lymphocytes.
- They provide costimulatory signals that regulate T cell responses.
- A soluble form of B7H4 has also been detected.
- B7X / VTCN1 / B7H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation; proliferation; cytokine production and development of cytotoxicity.
- When expressed on the cell surface of tumor macrophages; B7X / VTCN1 / B7H4 plays an important role; together with regulatory T-cells（Treg）; in the suppression of tumor-associated antigen-specific T-cell immunity.
- B7X / VTCN1 / B7H4 is also involved in promoting epithelial cell transformation.
- This membrane protein can be up-regulated by IL6 / interleukin-6 and IL10 / interleukin-10 and inhibited by CSF2 / GM-CSF and IL4 / interleukin-4 on antigen-presenting cells.
仕様
- サイズ：20ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：＞95 ％ as determined by reducing SDS-PAGE.
- エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
- アクセッションNo.：Q7Z7D3
- アミノ酸配列：Phe29-Ala258
- 遺伝子構造：A DNA sequence encoding the human VTCN1（Q7Z7D3） （Phe29-Ala258） with a C-terminal polyhistidine tag was expressed.
- 別名（遺伝子名）：B7S1; B7x; Vtcn1; B7h.5; B7-H4; B7H4T-cell costimulatory molecule B7x; B7S1VCTN1; B7XPRO1291; FLJ22418; Immune costimulatory protein B7-H4; Protein B7S1; T cell costimulatory molecule B7x; V-set domain containing T cell activation inhibitor 1; V-set domain-containing T-cell activation inhibitor 1
- 分子量：26.8 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4.
- 保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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84-9356-65
Recombinant Human B7-H4/VTCN1 Protein （aa 29-258, His Tag） 100ug
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84-9356-64
Recombinant Human B7-H4/VTCN1 Protein （aa 29-258, His Tag） 20ug
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84-9363-20
Recombinant Human B7-H4/VTCN1 Protein （aa 29-258, His Tag） 1mg
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