84-9356-59　［取扱停止］Recombinant Human KIR2DL1/CD158a Protein （His Tag） 100ug　PDMH100002

特徴

• 背景：Killer cell immunoglobulin-like receptor 2DL1 or KIR2DL1 is an inhibitory natural Killer cell immunoglobulin-like receptor with two extracellular immunoglobulin domains.
• KIR2DL1 is a member of the Killer cell immunoglobulin-like receptor family whose members are classified by the number of the extracellular immunoglobulin domains and the length of the cytoplasm domain.
• KIR2DL1 is a transmembrane glycoprotein expressed by natural killer cells and subsets of T cells.
• KIR2DL1 down-regulates the cytotoxicity of NK cells upon recognition of specific class I major histocompatibility complex （MHC） molecules on target cells.
• It has been reported that the KIR2DL1 bound to its class I MHC ligand; HLA-Cw4.
• The KIR2DL1-HLA-Cw4 interface exhibits charge and shape complementarity.
• Specificity is mediated by a pocket in KIR2DL1 that hosts the Lys80 residue of HLA-Cw4.
• Many residues conserved in HLA-C and in KIR2DL receptors make different interactions in KIR2DL1-HLA-Cw4 and in a previously reported KIR2DL2-HLA-Cw3 complex.
• A dimeric aggregate of KIR-HLA-C complexes was observed in one KIR2DL1-HLA-Cw4 crystal.