84-9352-15　［取扱停止］Recombinant Mouse GSTM1 Protein （His Tag） 100ug　PDEM100010

特徴

• 背景：Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families.
• At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified： alpha, kappa, mu, omega, pi, sigma, theta and zeta.
• This gene encodes a glutathione S-transferase that belongs to the mu class.
• The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione.
• The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic.
• These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs.
• Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens.
• Multiple protein isoforms are encoded by transcript variants of this gene.