84-9352-10　［取扱停止］Recombinant Mouse DNMT1 Protein （His Tag） 20ug　PDEM100008

特徴

• 背景：Methylates CpG residues.
• Preferentially methylates hemimethylated DNA.
• Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance.
• Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication.
• It is responsible for maintaining methylation patterns established in development.
• DNA methylation is coordinated with methylation of histones.
• Mediates transcriptional repression by direct binding to HDAC2.
• In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9.
• Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes （TSGs） or other tumor-related genes in colorectal cancer （CRC） cells.
• Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells （ESCs）.
• Associates at promoter regions of tumor suppressor genes （TSGs） leading to their gene silencing.
• Promotes tumor growth.