84-9352-05 ［取扱停止］Recombinant Mouse alpha-Synuclein/SNCA Protein （His Tag） 100ug PDEM100005
[Elabscience]
特徴
- 背景：Alpha-synuclein （Snca） belongs to a family of proteins including a-, b-, and g-synucleins.
- Alpha-synuclein has been found to be implicated in the pathophysiology of many neurodegenerative diseases, including Parkinson's disease （PD） and Alzheimer's disease.
- Manyneurodegenerative diseases has shown that alpha-synuclein accumulates in dystrophic neurites and in Lewy bodies.
- The function of alpha-synuclein is closely correlated with its three-dimensional structure, especially for proteins important in the pathogenesis of neurodegenerative diseases.
- Alpha-synuclein is a dynamic molecule whose secondary structure depends on the environment.
- For example, it has an unfolded random coil structure in aqueous solution, forms a-helical structure upon binding to acidic phospholipid vesicles, and forms insoluble fibrils with a high b-sheet content that resemble the filaments found in Lewy bodies.
- Also, alpha-synuclein was known to associate with 14-3-3 proteins including protein kinase C, BAD, and extracellular regulated kinase, and overexpression of alpha-synuclein could contribute to cell death in neurodegenerative diseases.
仕様
- サイズ：100ug
- 種由来：Mouse
- 発現宿主：E.coli
- 純度：＞95 ％ as determined by reducing SDS-PAGE.
- エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
- アクセッションNo.：O55042
- アミノ酸配列：Met1-Ala140
- 遺伝子構造：Recombinant Mouse alpha-Synuclein is produced by our E.coli expression system and the target gene encoding Met1-Ala140 is expressed with a 6His tag at the N-terminus.
- 別名（遺伝子名）：Alpha-synuclein; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP; Snca
- 分子量：15.9 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
- 保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
- メーカーマニュアルリンク：メーカーマニュアルはこちら
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84-9352-05
Recombinant Mouse alpha-Synuclein/SNCA Protein （His Tag） 100ug
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84-9352-04
Recombinant Mouse alpha-Synuclein/SNCA Protein （His Tag） 20ug
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