84-9352-03　［取扱停止］Recombinant Mouse S100B Protein （His Tag） 100ug　PDEM100004

特徴

• 背景：S100-B, is an acidic protein with a molecular weight of 21 kDa belonging to the S100 family.
• S100-B contains two EF-hand-type calcium-binding motifs separated by a hinge region with a hydrophobic cleft.
• S100-B plays an important role in neurodevelopment, differentiation, and brain construction.
• S100-B has neuroprotective effects, but at high concentrations S100-B is neurotoxic.
• Extracellular concentration of S100-B increases following brain damage, which easily penetrates into cerebrospinal fluid in brain damage and then into the blood.
• S100-B is expressed and produced by astrocytes in vertebrate brains and in the CNS, and the astrocytes are the major cells producing S100-B protein in gray matter, as well as oligodendrocytes are the predominant S100-B in protein producing cells in white matter.
• The major advantage of using S100-B is that elevations in serum or CSF levels provide a sensitive measure for determining CNS injury at the molecular level before gross changes develop, enabling timely delivery of crucial medical intervention before irreversible damage occurs.
• In addition, S100-B, which is also present in Mouse melanocytes, is a reliable marker for melanoma malignancy both in bioptic tissue and in serum.