84-9351-95　［取扱停止］Recombinant Mouse S100A1 Protein （His Tag）（Active） 20ug　PDEM100001

特徴

• 背景：S100A1 is a Ca2+binding protein of the EF-hand type that belongs to the S100 protein family.
• S100 proteins consisting of at least 19 members exist as dimers in the cytoplasm and/or nucleus of a wide range of cells, and are involved in the regulation of a number of cellular processes such as cell-cycle progression and cell differentiation.This protein has been shown to function in the processes including stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of PKC-mediated phosphorylation..
• Phosphoglucomutase is a target protein whose activity is antagonistically regulated by S100A1, and recently, S100A1 is also identified as a potent molecular chaperone and a new member of the Hsp70/Hsp90 multichaperone complex.
• S100A1 displays a tissue-specific expression pattern with highest levels in myocardium and is considered to be an important regulator of cardiac contractility.
• Accordingly, reduced expression or mutations of S100A1 gene have been implicated in cardiomyopathies.