84-9348-44 [取扱停止]Recombinant Human cyclin D1/Ccnd1 protein (His tag) 20ug PDEH100267
[Elabscience]特徴
- 背景:Activity of the cyclin-dependent kinases CDK4 and CDK6 is regulated by T-loop phosphorylation, by the abundance of their cyclin partners (the D-type cyclins), and by association with CDK inhibitors of the Cip/Kip or INK family of proteins.
- The inactive ternary complex of cyclin D/CDK4 and p27 Kip1 requires extracellular mitogenic stimuli for the release and degradation of p27 concomitant with a rise in cyclin D levels to affect progression through the restriction point and Rb-dependent entry into S-phase.
- The active complex of cyclin D/CDK4 targets the retinoblastoma protein for phosphorylation, allowing the release of E2F transcription factors that activate G1/S-phase gene expression.
- Levels of cyclin D protein drop upon withdrawal of growth factors through downregulation of protein expression and phosphorylation-dependent degradation.
仕様
- サイズ:20ug
- 種由来:Human
- 発現宿主:E.coli
- 純度:>95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度:Please contact us for more information.
- アクセッションNo.:P25322
- アミノ酸配列:Met 1-Ile 295
- 遺伝子構造:A DNA sequence encoding the Human cyclin D1/Ccnd1 protein (P25322) (Met 1-Ile 295) was expressed with N-His.
- 別名(遺伝子名):B cell leukemia 1;BCL 1;ccnd1;Cd1;Cyl 1;G1/S specific cyclin D1;PRAD1
- 分子量:32.34 kDa
- 組成:Lyophilized from sterile PBS, pH 7.4.
- 保存条件:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク:メーカーマニュアルはこちら
- この商品は法規制を確認しておりません。(法規制によって販売できない場合もございます)
- 【試薬に関するお問合せ】
- アズワン株式会社 試薬・プロセス材料グループ
- TEL:06-6447-8641
- FAX:06-6447-8642
- E-mail:[email protected]
商品のバリエーション (サイズ違い・スペック違い・オプション品など)
| 商品イメージ | アズワン品番 商品名 |
|---|---|
|
84-9348-44
Recombinant Human cyclin D1/Ccnd1 protein (His tag) 20ug
|
|
|
84-9348-45
Recombinant Human cyclin D1/Ccnd1 protein (His tag) 100ug
|
よくあるご質問(FAQ)
掲載カタログ情報
| 掲載カタログ名 | 掲載ページ |
|---|





