84-9347-87 [取扱停止]Recombinant Human Cyclin D1 protein (His tag) 20ug PDEH100238
[Elabscience]特徴
- 背景:Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition.
- Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase.
- Hypophosphorylates RB1 in early G1 phase.
- Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals.
- Also a substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity.
- Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
- Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner.
仕様
- サイズ:20ug
- 種由来:Human
- 発現宿主:E.coli
- 純度:>95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度:Please contact us for more information.
- アクセッションNo.:P24385
- アミノ酸配列:Ala 16-Ala 271
- 遺伝子構造:A DNA sequence encoding the Human Cyclin D1 protein (P24385) (Ala 16-Ala 271) was expressed with a N-His tag.
- 別名(遺伝子名):B cell leukemia 1;BCL 1;ccnd1;Cd1;Cyl 1;G1/S specific cyclin D1;PRAD1
- 分子量:28.05 kDa
- 組成:Lyophilized from sterile PBS, pH 7.4.
- 保存条件:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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商品のバリエーション (サイズ違い・スペック違い・オプション品など)
| 商品イメージ | アズワン品番 商品名 |
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84-9347-88
Recombinant Human Cyclin D1 protein (His tag) 100ug
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84-9347-87
Recombinant Human Cyclin D1 protein (His tag) 20ug
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