84-9344-91　［取扱停止］Recombinant Human Rac1 protein（His tag） 100ug　PDEH100086

特徴

• 背景：Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states.
• In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles （PubMed：', ', PubMed：', '）.', ' Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages.
• Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly.
• Stimulates PKN2 kinase activity （PubMed：', '）.', ' In concert with RAB7A, plays a role in regulating the formation of RBs （ruffled borders） in osteoclasts （PubMed：', '）.', ' In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning.
• Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin （CFL1） and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation.
• In neurons, is involved in dendritic spine formation and synaptic plasticity （By similarity）.', ' In hippocampal neurons, involved in spine morphogenesis and synapse formation, through local activation at synapses by guanine nucleotide exchange factors （GEFs）, such as ARHGEF6/ARHGEF7/PIX （PubMed：', '）.', ' In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3.
• In neurons, plays a crucial role in regulating GABA（A） receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in PAK1 activation and eventually F-actin stabilization （By similarity）.