84-9344-18　［取扱停止］Recombinant Human IL-6 Protein （His Tag）（Active） 20ug　PDEH100050

特徴

• 背景：Interleukin-6 （IL-6） is a pleiotropic, alpha -helical, 22-28 kDa phosphorylated and variably glycosylated cytokine that plays important roles in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression.
• IL-6 induces signaling through a cell surface heterodimeric receptor complex composed of a ligand binding subunit （IL-6 R alpha） and a signal transducing subunit （gp130）.
• IL-6 binds to IL-6 R alpha, triggering IL-6 R alpha association with gp130 and gp130 dimerization.
• Soluble forms of IL-6 R alpha are generated by both alternative splicing and proteolytic cleavage.
• In a mechanism known as trans-signaling, complexes of soluble IL-6 and IL-6 R alpha elicit responses from gp130-expressing cells that lack cell surface IL-6 R alpha.
• Trans-signaling enables a wider range of cell types to respond to IL-6, as the expression of gp130 is ubiquitous, while that of IL-6 R alpha is predominantly restricted to hepatocytes, monocytes, and resting lymphocytes.
• Soluble splice forms of gp130 block trans-signaling from IL-6/IL-6 R alpha but not from other cytokines that use gp130 as a co-receptor.
• IL-6, along with TNF-alpha and IL-1, drives the acute inflammatory response and the transition from acute inflammation to either acquired immunity or chronic inflammatory disease.
• When dysregulated, it contributes to chronic inflammation in obesity, insulin resistance, inflammatory bowel disease, arthritis, sepsis, and atherosclerosis.
• IL-6 can also function as an anti-inflammatory molecule, as in skeletal muscle where it is secreted in response to exercise.