84-9343-91　［取扱停止］Recombinant Human GAPDH protein （His Tag） 20ug　PDEH100037

特徴

• 背景：Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively.
• Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis.
• Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC.
• Modulates the organization and assembly of the cytoskeleton.
• Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules （By similarity）.
• Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate （G3P） into 3-phospho-D-glyceroyl phosphate.
• Component of the GAIT （gamma interferon-activated inhibitor of translation） complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes.
• Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs （such as ceruplasmin） and suppresses their translation.