84-9343-79 ［取扱停止］Recombinant Human CD247/CD3-ZETA Protein（His,SUMO） 20ug PDEH100031
[Elabscience]
特徴
- 背景：CD247, also known as CD3-ZETA, belongs to the CD3Z/FCER1G family.
- It contains 3 ITAM domains.
- As a -cell receptor zeta, CD247 forms the T-cell receptor-CD3 complex together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and ＆ndash;epsilon.
- The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways.
- Low expression of the antigen results in impaired immune response.
- Two alternatively spliced transcript variants encoding distinct isoforms have been found for CD247 gene.
- Defects in CD247 can cause immunodeficiency due to defect in CD3-zeta.
- An immunological deficiency characterized by T-cells impaired immune response to alloantigens, tetanus toxoid and mitogens.
- CD247 may play a role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.
仕様
- サイズ：20ug
- 種由来：Human
- 発現宿主：E.coli
- 純度：＞85 ％ as determined by reducing SDS-PAGE.
- エンドトキシン濃度：Please contact us for more information.
- アクセッションNo.：P20963
- アミノ酸配列：Arg52-Arg164
- 遺伝子構造：A DNA sequence encoding the Human CD247/CD3-ZETA protein （P20963） （Arg52-Arg164） was expressed with a N-His-SUMO tag.
- 別名（遺伝子名）：CD3-ZETA;CD3H;CD3Q;CD3Z;IMD25;T3Z;TCRZ
- 分子量：13 kDa
- 組成：Lyophilized from sterile 20mM Tris-HCl, 150 mM NaCI, 1 mM DTT （ pH 8.0）, Mannitol, Proclin300, Tween 80
- 保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
- メーカーマニュアルリンク：メーカーマニュアルはこちら
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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84-9343-80
Recombinant Human CD247/CD3-ZETA Protein（His,SUMO） 100ug
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84-9343-79
Recombinant Human CD247/CD3-ZETA Protein（His,SUMO） 20ug
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