It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability.
Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis.
Substantial evidence implicates VEGF in the induction of tumor metastasis and intra-ocular neovascular syndromes.
VEGF signals through the three receptors; fms-like tyrosine kinase （flt-1）, KDR gene product （the murine homolog of KDR is the flk-1 gene product） and the flt4 gene product.
The BioGems Murine VEGF Pre-Coated ELISA （Enzyme-Linked Immunosorbent Assay） kit is a solid phase immunoassay specially designed to measure Murine VEGF with a 96-well strip plate that is pre-coated with rat monoclonal antibody specific for VEGF.
It contains sf21-expressed recombinant Murine VEGF.
The detection antibody is a biotinylated goat polyclonal antibody specific for VEGF.
The kit is analytically validated with ready to use reagents.
