IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses.
Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions.
It stimulates B cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism.
IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R ＆alpha; and gp130.
Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells.
The BioGems Murine IL-6 Pre-Coated ELISA （Enzyme-Linked Immunosorbent Assay） kit is a solid phase immunoassay specially designed to measure Murine IL-6 with a 96-well strip plate that is pre-coated with rat monoclonal antibody specific for IL-6.
It contains E.coli-expressed recombinant Murine IL-6.
The detection antibody is a biotinylated goat polyclonal antibody specific for IL-6.
The kit is analytically validated with ready to use reagents.
