IL-31 is a T cell-derived cytokine that shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1.
It signals through a receptor complex comprised of GPL （also known as gp130-like receptor or IL-31RA） and Oncostatin-M receptor （OSMR）.
GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, JAK1, and JAK2 signaling pathways.
IL-31-regulated immune responses have been implicated in skin physiology and inflammatory skin diseases.
The BioGems Murine IL-31 Pre-Coated ELISA （Enzyme-Linked Immunosorbent Assay） kit is a solid phase immunoassay specially designed to measure IL-31 with a 96-well strip plate that is pre-coated with mouse monoclonal antibody specific for IL-31.
It contains E.coli-expressed recombinant IL-31.
The detection antibody is a biotinylated goat polyclonal antibody specific for IL-31.
The kit is analytically validated with ready to use reagents.
