Programmed death-ligand 1 （PD-L1） is a typ1 transmembrane glycoprotein also known as CD274 and was first characterized as an immune regulatory molecule, B7-H1.
The PD-1 receptor is found on activated B cells, T cells, and myeloid cells and modulates activation and inhibition.
The binding of PD-L1 to the PD-1 receptor on T cells delivers a signal that inhibits the TCR-mediated activation of IL-2 production and T cell proliferation.
Research has determined that the upregulation of PD-L1 may allow cancers to evade the host immune system.
The BioGems Human PD-L1/B7-H1 Pre-Coated ELISA （Enzyme-Linked Immunosorbent Assay） kit is a solid phase immunoassay specially designed to measure Human PD-L1/B7-H1 with a 96-well strip plate that is pre-coated with mouse monoclonal antibody specific for B7-H1/PD-L1.
It contains NS0-expressed recombinant Human PD-L1/B7-H1.
The detection antibody is a biotinylated goat polyclonal antibody specific for PD-L1/B7-H1.
The kit is analytically validated with ready to use reagents.
