IL-6 mediates its biological effects through the type I IL-6 receptor system that consists of two chains, IL-6Rα and gp130.
While the IL-6Rα chain is the binding component specific to IL-6, the gp130 chain only transmits signals of IL-6 when bound to IL-6Rα.
The gp130 can also transmit signals from LIF, OSM, CNTF, IL-11 and CT-1 in conjunction with other receptor subunits.
The low-affinity binding site for IL-6 is composed of IL-6Rα alone.
IL-6Rα is expressed in a wide range of cells, including T cells, fibroblasts and macrophages.
The BioGems Human IL-6 Receptor Pre-Coated ELISA （Enzyme-Linked Immunosorbent Assay） kit is a solid phase immunoassay specially designed to measure IL-6 Receptor with a 96-well strip plate that is pre-coated with mouse monoclonal antibody specific for IL-6 Receptor.
It contains sf21-expressed recombinant IL-6 Receptor.
The detection antibody is a biotinylated goat polyclonal antibody specific for IL-6 Receptor.
The kit is analytically validated with ready to use reagents.
