Fas and Fas Ligand （FasL） belong to the TNF superfamily, and are type I and type II transmembrane proteins, respectively.
Binding of FasL to Fas triggers apoptosis in Fas-bearing cells.
The mechanism of apoptosis involves recruitment of pro-caspase 8 through an adaptor molecule called FADD, followed by processing of the pro-enzyme into active forms.
These active caspases then cleave various cellular substrates, leading to the eventual cell death.
sFasR is capable of inhibiting FasL-induced apoptosis by acting as a decoy receptor that serves as a sink for FasL.
The BioGems Human FAS Pre-Coated ELISA （Enzyme-Linked Immunosorbent Assay） kit is a solid phase immunoassay specially designed to measure FAS with a 96-well strip plate that is pre-coated with mouse monoclonal antibody specific for FAS.
It contains NS0-expressed recombinant FAS.
The detection antibody is a biotinylated goat polyclonal antibody specific for FAS.
The kit is analytically validated with ready to use reagents.
