Activin A is a TGF-β family member that exhibits a wide range of biological activities, including regulation of cellular proliferation and differentiation, and promotion of neuronal survival.
Elevated levels of Activin A in human colorectal tumors and in postmenopausal women have been implicated in colorectal and breast cancers, respectively.
The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-β antagonist, follistatin.
Activin A binds to the two forms of activin receptor type I （Act RI-A and Act RI-B） and two forms of activin receptor type II （Act RII-A and Act RII-B）.
Activins are homodimers or heterodimers of different β subunits.
They are produced as precursor proteins with an amino terminal propeptide that is cleaved to release the C-terminal bioactive ligand.
The BioGems Human Activin A Pre-Coated ELISA （Enzyme-Linked Immunosorbent Assay） kit is a solid phase immunoassay specially designed to measure Activin A with a 96-well strip plate that is pre-coated with mouse monoclonal antibody specific for Activin A.
It contains CHO-expressed recombinant Activin A.
The detection antibody is a biotinylated goat polyclonal antibody specific for Activin A.
The kit is analytically validated with ready to use reagents.
