The 17B7 monoclonal antibody specifically binds to mouse and rat IL-17A, a pro-inflammatory cytokine.
It is produced by T helper 17 （Th17） cells, a unique subset of IL-23 dependent CD4+ T cells.
Interleukin-17A is highly expressed in transplant rejection, asthma, psoriasis, and multiple sclerosis, and enhances the expression of ICAM-1 in human fibroblasts.
The homodimer is expressed by activated peripheral CD4+ T lymphocytes.
The Interleukin-17A binds to the IL-17 receptors （IL-17R） expressed by mast cells, monocytes and macrophages, fibroblasts, and endothelial and epithelial cells.
