The 1A8 monoclonal antibody specifically reacts with the 21-25 kDa glycophosphatidylinositol-anchored protein known as Ly-6G, expressed by the granulocytes from the bone marrow and periphery neutrophils.
Ly-6G and Ly-6C form the Granulocyte Receptor-1 antigen （GR-1）.
The binding of the 1A8 antibody to the Ly-6G can be blocked by another antibody, RB6-8C5, which also recognizes Ly-6C.
While 1A8 is specific for only Ly-6G, RB6-8C5 also binds to Ly-6C.
