84-7743-49　Anti-Mouse KLRG1 BG Violet 450 25 ug　82112-40-25

仕様

• サイズ：25 ug
• The 2F1 monoclonal antibody is specific for the mouse Killer cell Lectin-like Receptor G1 （KLRG1）, a homodimer consisting of two N-glycosylated subunits of 30-38 kDa, also known as MAFA （Mast cell Function-associated Antigen）.
• The antigen contains a cytoplasmic motif similar to ITIM （the immunoreceptor tyrosine-based inhibitory motif）.
• KLRG1 is a receptor for cadherin, a family of transmembrane glycoproteins that mediate cell adhesion, and a common marker of T cell senescence.
• The receptor is believed to play an important role in the innate and adaptive immune system through the regulation of leukocytes.
• It is expressed on lymphokine-activated killer （LAK） cells, adherent LAK （A-LAK） cells, a sub-set of natural killer （NK） cells, T cells.
• In NK cells, it inhibits cytokine production and cytotoxicity activity.
• The receptor expression was not detected on the mouse peritoneal mast cells, or bone marrow mast cells.
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