IL-1α is a non-secreted, proinflammatory cytokine produced in a variety of cells, including monocytes, tissue macrophages, keratinocytes and other epithelial cells.
Both IL-1α and IL-1β bind to the same receptor and have similar, if not identical, biological properties.
These cytokines have a broad range of activities including the stimulation of thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity, and the release of prostaglandin and collagenase from synovial cells.
However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine.
The ALF-161 monoclonal antibody reacts with the precursor, secreted and membrane-associated forms of mouse IL-1 α.
The antibody is reported to be usable as the capture antibody in an ELISA assay and exhibits neutralization properties.
