84-7741-63　Anti-Mouse CD62L (L-Selectin) FITC 500ug　04712-50-500

仕様

• サイズ：500ug
• The MEL-14 monoclonal antibody specifically reacts with L- selectin （CD62L）, a receptor with lectin-like and Epidermal Growth Factor-like domains.
• The weight of the CD62L molecules depend on their origin, 74 kDa on lymphocytes or 95 kDa on neutrophils.
• In the mouse organism, CD62L can be expressed by most thymocytes, on subsets of B and T lymphocytes, monocytes, eosinophils, and neutrophils.
• The L-selectin binds sulfated, fucosylated, and glycosylated glycoproteins （MadCAM-1, GLYCAM-1, and CD 34）.
• It mediates the migration of lymphocytes to the site of inflammation and their return to the peripheral lymphoid tissues and to the HEV （high endothelial venules）.
• In vitro, L-selectin inhibits this binding and the lymphocyte extravasation into peripheral lymph nodes.
• After cell activation, it is quickly shed by neutrophils and lymphocytes.
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