84-7741-41　Anti-Mouse CD45.2 FITC 25 ug　07532-50-25

仕様

• サイズ：25 ug
• The 104 monoclonal antibody specifically reacts with the mouse CD45 molecule, the Leukocyte Common Antigen （LCA） which occurs in the alloantigen CD45.2-expressing mouse strains （C57BL/6, CBA, 129, A, AKR, C58, DBA/1, DBA/2, BALB/c, and C3H/He）.
• The 104 monoclonal antibody does not react with the leukocytes of the CD45.1-expressing mouse strains （DA, SJL/J, RIII, and STS/A）.
• The CD45 molecule is a member of the Protein Tyrosine Phosphatase （PTP） family, because its intracellular region contains two PTP domains.
• The extracellular region's variability is caused by different levels of glycosylation, and the splicing of the 4, 5, and 6 exons.
• The isoforms found in the mouse strains depend on the activation state, maturation stage and cell type, and are very important in B and T lymphocytes antigen receptor signal transduction.
• The 104 antibody inhibits some of the B lymphocytes responses, reduces the serum IgG levels, and influences the autoimmune renal pathology.
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