84-7740-28　Anti-Mouse CD357 (AITR / GITR) FITC 25ug　39612-50-25

仕様

• サイズ：25ug
• The DTA-1 monoclonal antibody specifically reacts with mouse Glucocorticoid-Induced TNFR-related protein, also known as GITR and TNFRSF18, a 66-70 kDa homodimer glycoprotein, detected in the T cells treated with glucocorticoid dexamethasone.
• GITR is also expressed in naive mice by CD25+/CD4+/CD8a- thymocytes and on CD25+/CD4+/CD45RB-low splenocytes.
• Low levels were detected in splenic CD25+/CD4+/CD45RB-low T cells, B cells, dendritic cells and macrophages.
• A GITR ligand was detected on dendritic cells, macrophages and B cells.
• The DTA-1 antibody stimulates GITR and abrogates suppression by T regulatory cells （Treg）, without affecting their proliferation.
• DTA-1 administration or the removal of GITR-expressing cells led to organ specific autoimmune disease.
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