84-7739-64　Anti-Mouse CD279 (PD-1) Purified 100ug　31812-20-100

仕様

• サイズ：100ug
• The J43.1 monoclonal antibody specifically reacts with mouse CD279, also known as PD-1 （programmed death-1）, a 50-55 kDa glycoprotein of the Ig superfamily.
• The PD-1 ligands, PD-L1 （B7-H1） and PD-L2 （B7-H2） are members of the B7 family.
• Pd-1 contains an Immunoreceptor Tyrosine-based Inhibitory Motif （ITIM） and influences the peripheral tolerances and autoimmune diseases in mice.
• PD-1 is transiently expressed on CD4/CD8 thymocytes, it is upregulated in apoptotic cells, and it is expressed by activated myeloid and T and B cells.
• The binding of PD-1 to its ligands is blocked by the J43 antibody, which also enhances contact hypersensitivity and exacerbates acute Graft-versus-host disease, Experimental autoimmune encephalomyelitis and NOD diabetes.
• PD-1 seems to downregulate the immune response, as the development of splenomegaly and breakdown of peripheral tolerance in PD-1 deficient mice suggests.
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